ZO Skin Health Daily Power Defense

ZO Skin Health Daily Power Defense is a next-generation advanced serum clinically proven to strengthen the skin’s protective barrier while defending against environmental stressors and premature signs of aging. Elevated with ZO®’s exclusive technologies — including the new ZPOLY™ plant-derived polysaccharide complex, ZO-RRS2® plant stem cell complex, potent antioxidant vitamins A and E, and specialized DNA-repair enzymes — this daily serum enables a long-lasting, youthful, and healthy skin complexion with consistent twice-daily use.

Formulated for all skin types, Daily Power Defense addresses the full spectrum of environmental and age-related skin damage in a single daily serum: neutralizing free radicals, accelerating barrier restoration, extending skin hydration, soothing visible redness, and visibly reducing premature signs of aging. It is a foundational staple of the ZO® Skin Health regimen, designed to be used morning and evening as the cornerstone of long-term skin health maintenance.

Skin Types

Suitable for all skin types. Its comprehensive barrier-strengthening and antioxidant formula is appropriate for dry, normal, oily, combination, and sensitive skin types seeking daily environmental protection and anti-aging correction.

Skin Concerns

Formulated to address premature signs of aging caused by environmental free radical damage, barrier dysfunction, dehydration, and oxidative stress. Also addresses visible redness and skin sensitivity associated with a compromised barrier. Ideal for those seeking a single daily serum that simultaneously protects, repairs, and hydrates.

Benefits

• Clinically proven to strengthen the skin’s protective barrier
• Defends skin against oxidative damage from environmental free radicals
• Visibly reduces signs of premature aging with continued daily use
• Accelerates barrier restoration for faster skin recovery
• Extends skin hydration with the ZPOLY™ polysaccharide complex
• Soothes visible redness with the ZO-RRS2® plant stem cell complex
• Supports continuously healthy, resilient skin
• Suitable for all skin types; morning and evening use

Key Ingredients

• Vitamins A + E — A potent antioxidant duo that works synergistically to protect the skin against environmental aging caused by UV exposure, pollution, and other free radical-generating aggressors. Vitamin A (retinyl palmitate) supports cell turnover and skin renewal, while vitamin E (tocopherol) neutralizes free radicals and replenishes the skin’s lipid barrier — together delivering comprehensive antioxidant defence and anti-aging correction.
• ZO-RRS2® (Plant Stem Cell Complex) — ZO®’s exclusive plant stem cell complex that helps neutralize damaging free radicals while simultaneously soothing visible redness. Its dual antioxidant and anti-inflammatory action addresses both the oxidative damage and the inflammatory response that contribute to premature skin aging and barrier dysfunction.
• ZPOLY™ (Plant-Derived Polysaccharide Complex) — ZO®’s exclusive plant-derived polysaccharide complex that minimizes signs of premature aging while infusing extended, long-lasting hydration into the skin. ZPOLY™ supports the skin’s protective barrier function and helps maintain optimal moisture balance throughout the day, accelerating barrier restoration and reducing transepidermal water loss.
• Micrococcus Lysate + Arabidopsis Thaliana Extract — Specialized enzymatic actives that encourage optimum skin cell health by supporting the skin’s natural DNA repair mechanisms. Micrococcus lysate contains photolyase enzymes that help repair UV-induced DNA damage, while arabidopsis thaliana extract provides additional cellular protection and resilience against environmental stressors.

Clinical Evidence

Daily Power Defense was evaluated in a 12-week independent, third-party clinical study of 38 subjects — females aged 47–70 across Fitzpatrick skin types I–V — to assess its efficacy in strengthening the skin’s barrier and reducing premature signs of aging. The study was conducted with concurrent use of ZO® Gentle Cleanser and Sunscreen + Primer Broad-Spectrum SPF 30. Results demonstrated clinically meaningful improvements in barrier function, skin hydration, and visible signs of aging over the 16-week assessment period.

How to Use

Apply Daily Power Defense to clean, dry skin each morning and evening. Allow to absorb fully before applying moisturizer and sunscreen. For best results, use consistently twice daily as part of a complete ZO® Skin Health regimen.